Large research programme alongide the electrophysiology and Rayne imaging teams looking at advanced imaging in patients undergoing cardiac resynchronisation with over 50 accepted abstracts over the last year
Fung, Butt A, Swaminathan S, Carr-White G
Circulating nucleic acid in the assessment of congestive heart failure

Benon, Higginson, Harding R, Coady E, Hodson F, Carr-White G
A project to develop and test a specialist palliative care service for patient s with heart failure within a cardiology outpatient clinic
· Integral part of EU research project into mathematical modelling of LV function

· Inherited caridac diseases: collaberation wwith UCL looking at genetic predictors of cardiac disease

· Pallaitive care: ongoing collaboration with Dr Beynon on optimal models of palliative care in heart failure patients

· MRI: Ongoing project looking at perfusion indices in LV hypertrophy
Two related studies in patients with repaired Tetralogy of Fallot and pulmonary regurgitation
V Parish, C Head, J Hancock and R Razavi
A comparison of echocardiography and MRI imaging for assessment of RV function


V Parish, C Head, J Hancock and R Razavi
Predicting the response to pulmonary valve replacement.  
Rudd A, Padayachee S, Woolf C, Chambers J
Echocardiography in the clinical typing of stroke
     
Chambers J, Ridsdale L, Seed P
Clopidogrel for the prophylactic treatment of migraine
      
A Tylee, Farmer A, I Morris, J Chambers, A Mann, J Murray,  D Rose, M Ashworth, R Churchill, P McCrone, Walters P, Lees M, Brown J
A programme of research to develop and test stepped care for patients with depression and symptomatic coronary artery disease in primary care (National Institute for Health Research: lead Prof A Tylee)
      
Rajani R, Parkin D, Chambers J
Cross-over trial of subcutaneous nerve stimulation in angina
      
Hart N, Chambers J, Davidson C, Howard R, Jungbluth H, Jones J, Williams A, Wraige E
Traditional service frameworks for children and young people with Duchenne Muscular Dystrophy and other progressive neuromuscular diseases
      
French W, Chambers J
The use of poetry to articulate patient concerns

Chambers J, Hunter M
A multidisciplinary clinic for atypical chest pain
THRIVE, assessing the effect on cardiovascular events of lowering LDL and raising HDL levels (lead CTSU, Oxford)
SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) to test the effect of lipid-lowering on coronary events or the rate of progression of aortic stenosis (Lead Acer Hospital, Oslo)
Evolution II register for the Monarch device
Edwards Source Registry
Echo CRT, a comparison of CRT on or off in patients requiring AICD
CASTLE AF comparing ablation vs standard therapy in patients with atrial fibrillation and reduced LV ejection fraction
Anti MRSA vaccine study
Prevail EU assessing Edwards TAVI in severe aortic stenosis
CRISP AMI.  PAMI study with or without balloon pump assessing infarct size using CMR
SOLSTICE assessing effect of losmapimod on infarct size in NSTEMI using CMR
RED HF assessing darbopeitin in the treatment of heart failure
ATMOSPHERE assessing the efficacy and safety of aliskiren as monotherapy or combined with enalapril in heart failure
Prevail TA assessing Edwards TAVI in severe aortic stenosis, via the transapical route
Xima, Drug eluting vs Bare metal stents in patient over the age of 80
Blast, angio vs IVUS guided bifurcation stenting
MRInform, MRI vs FFR guided intervention
Platinum, Promus vs Promus element stent
Resolution stent registry for resolute stent
PE Prove. Stent registry of Promus Element stent
ATMOSPHERE assessing the efficacy and safety of aliskiren as monotherapy or combined with enalapril in heart failure
Carr-White G, Razavi R                                            Coronary artery assessment by CT and MRI

Penney G, Chambers J, Razavi R                       Statistical modelling of endocardial movement
The themes remain the testing of replacement valves and the optimisation of timing for native valve surgery.

* A study of physical and psychological determinants of well-being after valve surgery has now finished. 
* A study of interactions between aortic physiology, LV function and aortic valve function forms part of Ronak Rajani’s MD thesis. 

Current studies include:
Rimington H, Hodson F, Chambers J, Blauth C
A randomized comparison of the Toronto Stentless and Baxter Pericardial valve.

Rajani R, Rimington H, Parkin D, Chambers J
Interactions between LV function, aortic valve function and aortic physiology in determining symptoms in patients with aortic stenosis.

 
Feneck R, Wielgorski A, Powroznyk A, Taylor E, Chawla   A, McCorkell S, Puchakayala M, Hunt T
Aortic valve area in elderly patients undergoing CABG

Rimington H, Parkin D, Lloyd G, Chambers J
Audit of sonographer/nurse-led valve clinic
     
Bridgewater B, Roxburgh J, Ray S, Chambers J
National variations in surgery for aortic stenosis

Parkin D, Chambers J
Patient s perception of replacement valve noise

Parkin D, Shabbo F, Chambers J
Mid-term clinical follow-up after aortic valve replacement with the Cryolife O Brien bioprosthesis

Parkin D, Chambers J.
Long-term follow-up of the On-X valve

Parkin D, Roxburgh J, Chambers J.
Early redo surgery.